Skip Navigation



NDT Plus Advance Access published online on February 26, 2009
NDT Plus, doi:10.1093/ndtplus/sfp025
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2/3/246    most recent
sfp025v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hill, P.
Right arrow Articles by Goodman, D.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection

Prue Hill1, John Slavin1 and David Goodman2

1 Department of Anatomical Pathology
2 Department of Nephrology, St Vincent's Hospital, Fitzroy 3065, Victoria, Australia

Correspondence: Prue Hill, Department of Anatomical Pathology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia. Tel: +61-3-92884549; Fax: +61-3-92884580; E-mail: prue.hill{at}svhm.org.au


  Abstract

Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting.

Key Words: BK virus • kidney transplant • PVN • urothelial carcinoma

Received for publication October 8, 2008. Accepted for publication February 10, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.