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NDT Plus Advance Access published online on February 18, 2009
NDT Plus, doi:10.1093/ndtplus/sfp020
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Rituximab in two cases of Goodpasture's syndrome

Birgit Schless1, Suzan Yildirim1, Daniel Beha1, Frieder Keller1 and David Czock2

1 Division of Nephrology, Medical Department, University Hospital, Ulm
2 Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany

Correspondence: Frieder Keller, Division of Nephrology, Medical Department I, University Hospital, Albert Einstein Allee 23, D-89070 Ulm, Germany. Tel: +49-731-500-44561; Fax: +49-731-500-44567; E-mail: frieder.keller{at}uniklinik-ulm.de


  Abstract

We describe the effects of rituximab in two patients with refractory Goodpasture's syndrome. After one single 1000 mg dose administration, rituximab did not appear to improve renal function in either of our cases. Polyoma virus-negative leukoencephalopathy, a probable toxic side effect of rituximab, was seen in our first patient.

Key Words: anti-GBM disease • Goodpasture’s syndrome • leukoencephalopathy • plasma exchange • rituximab

Received for publication January 13, 2009. Accepted for publication January 30, 2009.


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