Skip Navigation



NDT Plus Advance Access published online on January 6, 2009
NDT Plus, doi:10.1093/ndtplus/sfn200
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2/2/139    most recent
sfn200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gupta, R.
Right arrow Articles by Mehta, T.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Treatment of sarcoid granulomatous interstitial nephritis with adalimumab

Roopali Gupta1, Lisa Beaudet2, Jack Moore1 and Tulsi Mehta1

1 Department of Nephrology
2 Department of Pathology, Washington Hospital Center, Washington, DC, USA

Correspondence: Tulsi K. Mehta, MD, Section of Nephrology, 110 Irving Street, Suite 2A70, Washington, DC 20010, USA. Tel: +202-877-6034; Fax: +202-877-8329; E-mail: tulsi.mehta{at}medstar.net


  Abstract

Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. After therapy with adalimumab, her renal function improved with a significant reduction in proteinuria. Repeat kidney biopsy showed resolution of renal granulomata. To our knowledge, this is the first report of successful treatment of granulomatous interstitial nephritis with adalimumab.

Key Words: adalimumab • granulomatous interstitial nephritis • sarcoidosis • TNF-alpha inhibitors

Received for publication April 9, 2008. Accepted for publication December 2, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.