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NDT Plus Advance Access published online on May 25, 2008

NDT Plus, doi:10.1093/ndtplus/sfn058
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© The Author [2008]. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Successful treatment of inoperable recurrent secondary hyperparathyroidism with cinacalcet HCl

Rieko Eriguchi1, Junko Umakoshi1, Yoshihiro Tominaga2 and Yuzuru Sato1

1 Sato Junkanki Hospital, Matsuyama
2 Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan

Correspondence: Rieko Eriguchi, Asouda-cho 4-10-25, Matsuyama City, Ehime Prefecture 790-0952, Japan. Tel: +81-89-931-3355; Fax: +81-89-931-3431; E-mail: rieko-eriguchi@satohp.co.jp

Key Words: bone mineral density • cinacalcet • parathyromatosis • secondary hyperparathyroidism

Received for publication April 25, 2008. Accepted for publication April 28, 2008.

The first 10% of the full text of this article appears below.


    Introduction
 
Secondary hyperparathyroidism is a common complication for patients with end-stage renal disease (ESRD). When it progresses, it is associated with morbidity and mortality [1]. Phosphate binders and vitamin D can be used to prevent the progression of secondary hyperparathyroidism. However, these conservative treatments often fail to control severe hyperparathyroidism. In such cases, parathyroidectomy is required. Despite medical management after parathyroidectomy, persistent or recurrent hyperparathyroidism can occur. One of the causes of recurrent hyperparathyroidism is parathyromatosis, which has been described as multiple nodules or rests of hyperfunctioning parathyroid tissue that become evident following parathyroidectomy. We describe a female haemodialysis patient diagnosed with secondary hyperparathyroidism, which was probably caused by parathyromatosis. Treatment with cinacalcet, a calcimimetic agent, in combination with vitamin D was extremely effective.


    Case report
 
A 66-year-old . . . [Full Text of this Article]


    Discussion
 

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