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NDT Plus Advance Access published online on April 14, 2008
NDT Plus, doi:10.1093/ndtplus/sfn037
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Fibronectin glomerulopathy: an uncommon cause of nephrotic syndrome in systemic lupus erythematosus

Antonella Stoppacciaro1, Angelo Pietrucci2, Claudia Fofi2, Salvatore Raffa1, Maria Rosaria Torrisi1 and Paolo Menè2,3

1 Department of Experimental Medicine
2 Division of Nephrology
3 Department of Clinical Sciences, Sant’Andrea University Hospital, University ‘La Sapienza’ of Rome, Italy

Correspondence: Paolo Menè, Department of Clinical Sciences, U.O.C. Nefrologia, Azienda Ospedaliera Sant’Andrea, Via di Grottarossa 1035-1039, 00189 Rome, Italy. Tel: +39-06-3377-5949; Fax: +39-06-3377-5866; E-mail: paolo.mene@uniroma1.it

Key Words: fibrillary glomerulopathy • fibronectin • lupus nephritis • systemic lupus erythematosus

Received for publication January 14, 2008. Accepted for publication March 18, 2008.

The first 10% of the full text of this article appears below.


   Background
 
A renal biopsy in a case of systemic lupus erythematosus (SLE) nephritis presenting with both nephrotic syndrome (NS) and acute renal failure (ARF) demonstrated atypical fibrillary deposits in the glomerular mesangium and subendothelium. The size and morphology of fibrils resembled those of fibronectin (FN) glomerulopathy [1,2], as also confirmed by immunoperoxidase staining. As no familial history of FN disorders was noted, this case may represent the first report of a new kidney disease entity in the context of SLE.


   Case report
 
A 62-year-old man without previous known signs and symptoms of kidney disease presented with the abrupt onset of nephrotic syndrome (NS). On admission, massive limb and scrotal oedema, bilateral pleural effusion and mild ascites were noted, without other relevant physical signs. BP was . . . [Full Text of this Article]


   Renal histology
 
Follow-up

   Discussion
 

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