Skip Navigation


NDT Plus Advance Access originally published online on April 22, 2009
NDT Plus 2009 2(4):298-299; doi:10.1093/ndtplus/sfp046
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2/4/298    most recent
sfp046v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ruokoniemi, P.
Right arrow Articles by Laine, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Acetazolamide may provoke cyclosporine toxicity—a case report

Päivi Ruokoniemi1, Risto Tertti2, Pia Paalosmaa-Puusa3, Hannele Kareranta4 and Kari Laine1,5

1 Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland
2 Department of Internal Medicine, Turku University Hospital, Turku
3 Department of Internal Medicine
4 Department of Ophthalmology, Salo District Hospital, Salo
5 Department of Clinical Pharmacology, Tykslab, Health Care District of Southwest Finland, Turku, Finland

Correspondence: Correspondence and offprint requests to: Päivi Tuulikki Ruokoniemi; E-mail: paivi.ruokoniemi{at}utu.fi


  Abstract

We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide.

Key Words: acetazolamide • cyclosporine • drug interactions • renal transplantation

Received for publication April 2, 2009. Accepted for publication April 3, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.