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NDT Plus Advance Access originally published online on April 15, 2009
NDT Plus 2009 2(4):292-294; doi:10.1093/ndtplus/sfp037
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Acute renal failure after treatment with sunitinib in a patient with multiple myeloma

Nelson Leung1, Nathan A. Saucier1, Steven R. Zeldenrust2, Heidi D. Gunderson3 and Lynn D. Cornell4

1 Division of Nephrology and Hypertension
2 Division of Hematology
3 Department of Pharmacology
4 Department of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA

Correspondence: Correspondence and offprint requests to: Nelson Leung; E-mail: Leung.nelson{at}mayo.edu


  Abstract

Sunitinib is a multiple tyrosine kinase receptors inhibitor that is approved for the treatment of advanced renal cell carcinoma. Amongst its targets are fetal liver tyrosine kinase receptor 3 (FLT 3) and vascular endothelial growth factor receptor (VEGFR). Renal toxicity has not been reported from the trials, but several patients have been reported to develop a pre-eclampsia-like syndrome. We report the first case of acute tubular necrosis in a patient with multiple myeloma following treatment with sunitinib.

Key Words: acute renal failure • drug toxicity • sunitinib

Received for publication March 6, 2009. Accepted for publication March 17, 2009.


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