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NDT Plus Advance Access originally published online on February 9, 2009
NDT Plus 2009 2(3):250-253; doi:10.1093/ndtplus/sfp003
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Life-threatening adenovirus infection in a kidney transplant recipient

Katherine Barraclough1, Kimberley Oliver2, Elliot Geoffrey Playford3, John Preston4, Scott Campbell1, David W. Johnson1, Carmel Hawley1, David Mudge1, Carolyn van Eps1 and Nicole Isbel1

1 Department of Nephrology
2 Department of Anatomical Pathology
3 Infection Management Services
4 Department of Transplant Surgery, Princess Alexandra Hospital, Brisbane, Australia

Correspondence: Correspondence and offprint requests to: K. Barraclough, Department of Nephrology, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba 4102, Queensland, Australia. Tel: +617-32405080; Fax: +617-32405480; E-mail: katherine_barraclough@health.qld.gov.au

Key Words: adenovirus • kidney transplantation • cidofovir

Received for publication January 3, 2009. Accepted for publication January 6, 2009.

The first 150 words of the full text of this article appear below.


   Introduction
 
Adenovirus causes 5–10% of all childhood febrile illnesses [1]. In the immunocompetent host, infection is usually associated with mild, self-limiting upper respiratory tract syndromes. Most individuals have serologic evidence of prior adenoviral infection by age 10 [1]. Following initial infection, adenovirus establishes lifelong latent infection in lympho-epithelial tissues [2].

In immunocompromised hosts, the spectrum of adenovirus infection can range from asymptomatic shedding to fatal disseminated disease [2]. It may represent primary infection, usually the case in paediatric transplant recipients, or reactivation of latent disease. Latent viruses may be of donor or recipient origin [2].

Adenovirus infection has been documented in solid organ transplantation, but is relatively rare and therefore a paucity of epidemiologic data exists. This case of adenovirus infection in a kidney transplant recipient is unusual for the severity of allograft dysfunction and the life-threatening nature of disease. It . . . [Full Text of this Article]


   Case report
 

   Discussion
 

   Teaching points
 

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