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NDT Plus Advance Access originally published online on February 9, 2009
NDT Plus 2009 2(3):242-245; doi:10.1093/ndtplus/sfp013
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Late recovery of renal failure after autologous haematopoietic stem cell transplantation for multiple myeloma: a report of two cases

Naïke Bigé1, Bruno Guéry1, Richard Delarue2, Laure-Hélène Noël3 and Fadi Fakhouri1

1 Nephrology Department
2 Haematology Department
3 Pathology Department, Université Paris Descartes, AP-HP, Necker Hospital, Paris, France

Correspondence: Correspondence and offprint requests to: Fadi Fakhouri, Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK. Tel: +00442083832315; Fax: +00442083832379; E-mail: f.fakhouri{at}imperial.ac.uk


  Abstract

Acute renal failure is a frequent feature in patients with multiple myeloma (MM). MM-related renal insufficiency may improve after autologous haematopoietic stem cell transplantation (autoHSCT) even in patients initially requiring dialysis. Herein, we report on two unusual cases of late improvement in renal function occurring over more than 5 years after autoHSCT for MM. Clinicians must be aware that slow and progressive improvement in renal function may occur over years in patients with MM-associated renal failure. Our data underline the need for an aggressive treatment, including autoHSCT, in MM patients presenting with severe renal dysfunction.

Key Words: multiple myeloma • haematopoietic stem cell transplantation • renal disease

Received for publication January 15, 2009. Accepted for publication January 16, 2009.


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