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NDT Plus Advance Access originally published online on February 10, 2009
NDT Plus 2009 2(2):155-157; doi:10.1093/ndtplus/sfp010
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© The Author [2009].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis

Shunsuke Yamada1, Masatomo Taniguchi1, Masanori Tokumoto1, Kazuhiko Tsuruya1,2 and Mitsuo Iida1

1 Departments of Medicine and Clinical Science
2 Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan

Correspondence: Correspondence and offprint requests to: Kazuhiko Tsuruya, Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. Tel: +81-92-642-5843; Fax: +81-92-642-5846; E-mail: tsuruya{at}intmed2.med.kyushu-u.ac.jp


  Abstract

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the ‘left femur head’, which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the ‘left knee’ occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.

Key Words: calcitonin receptor • multi-nucleated giant cell • osteoclast • tumoral calcinosis

Received for publication April 30, 2008. Accepted for publication January 8, 2009.


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