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NDT Plus Advance Access originally published online on July 3, 2008
NDT Plus 2008 1(5):336-339; doi:10.1093/ndtplus/sfn077
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

BK virus induced nephritis in a boy with acute myeloid leukaemia undergoing bone marrow transplantation

Julia Hoefele1,*, Despina Rüssmann1,*, Barbara Klein2, Lutz T. Weber1 and Monika Führer2

1 Department of Pediatric Nephrology
2 Department of Transplantation, University Children's Hospital, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Munich, Germany

Correspondence: Correspondence and offprint requests to: Julia Hoefele, Department of Pediatric Nephrology, University Children's Hospital, Lindwurmstrasse 4, 80337 Munich, Germany. Tel: +49-89-5160-2857; Fax: +49-89-5160-2771; E-mail: julia.hoefele{at}med.uni-muenchen.de


  Abstract

BK virus (BKV) is a human polyomavirus. The primary infection occurs typically without specific signs or symptoms. Almost 80% of adults are seropositive. Clinically relevant infections are usually limited to individuals who are immunosuppressed. After primary infection, BKV remains latent in the kidneys and can be reactivated in the setting of immunosuppression. BKV is associated with tubulointerstitial nephritis and ureteric stenosis in renal transplant recipients. Furthermore, BKV-induced haemorrhagic cystitis (HC) is a severe complication of bone marrow transplantation (BMT) in children and adults. A combination of HC and tubulointerstitial nephritis in a patient has not been reported so far. We report on an 11-year-old boy with acute myeloid leukaemia undergoing BMT. BKV infection was reactivated during post-transplant immunosuppressive therapy causing HC associated with tubulointerstitial nephritis.

Key Words: bone marrow transplantation • haemorrhagic cystitis • interstitial nephritis • immunodeficiency • polyomavirus

Received for publication May 28, 2008. Accepted for publication May 30, 2008.

* These authors contributed equally to this work.


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