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NDT Plus Advance Access originally published online on August 1, 2008
NDT Plus 2008 1(5):300-302; doi:10.1093/ndtplus/sfn105
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Abrupt and durable remission of Henoch–Schönlein purpura nephritis with cyclosporine A

Eleni Georgaki-Angelaki1, Stavroula Kostaridou2, Athanasia Lourida2, C. Petraki3 and Evagelia Lagona2

1 Department of Paediatric Nephrology
2 Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens 11527
3 Nephropathology Department, Evangelismos Hospital, Athens, Greece

Correspondence: Correspondence and offprint requests to: Eleni Georgaki-Angelaki, Department of Paediatric Nephrology, Aghia Sophia Children's Hospital Athens, Thivon and Levadias Street, Athens 11527, Greece. Tel: +30-2107467097; Fax: +30-2107467097; E-mail: pednephr{at}paidon-agiasofia.gr


  Abstract

Henoch–Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with severe HSP-GN, but none have shown convincing favourable effects. We report a case of biopsy-proven HSP-related GN in a 4-year-old girl that responded remarkably well to cyclosporine A (CsA), following failure to respond to other immunosuppressive agents. At 8 months post-CsA treatment, repeat renal biopsy findings were consistent with histological improvement. We conclude that CsA treatment not only exerts beneficial effects on resistant HSP-related GN but may also arrest progression of the disease.

Key Words: cyclosporine A • glomerulonephritis • Henoch–Schönlein purpura

Received for publication April 15, 2008. Accepted for publication June 26, 2008.


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