NDT Plus Advance Access originally published online on May 25, 2008
NDT Plus 2008 1(4):218-220; doi:10.1093/ndtplus/sfn058
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© The Author [2008].
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Successful treatment of inoperable recurrent secondary hyperparathyroidism with cinacalcet HCl
1 Sato Junkanki Hospital, Matsuyama
2 Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
Correspondence: Rieko Eriguchi, Asouda-cho 4-10-25, Matsuyama City, Ehime Prefecture 790-0952, Japan. Tel: +81-89-931-3355; Fax: +81-89-931-3431; E-mail: rieko-eriguchi@satohp.co.jp
Key Words: bone mineral density • cinacalcet • parathyromatosis • secondary hyperparathyroidism
Received for publication April 25, 2008. Accepted for publication April 28, 2008.
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Introduction |
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Secondary hyperparathyroidism is a common complication for patients with end-stage renal disease (ESRD). When it progresses, it is associated with morbidity and mortality [1]. Phosphate binders and vitamin D can be used to prevent the progression of secondary hyperparathyroidism. However, these conservative treatments often fail to control severe hyperparathyroidism. In such cases, parathyroidectomy is required. Despite medical management after parathyroidectomy, persistent or recurrent hyperparathyroidism can occur. One of the causes of recurrent hyperparathyroidism is parathyromatosis, which has been described as multiple nodules or rests of hyperfunctioning parathyroid tissue that become evident following parathyroidectomy. We describe a female haemodialysis patient diagnosed with secondary hyperparathyroidism, which was probably caused by parathyromatosis. Treatment with cinacalcet, a calcimimetic agent, in combination with vitamin D was extremely effective.
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Case report |
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A 66-year-old
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