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NDT Plus Advance Access originally published online on March 27, 2008
NDT Plus 2008 1(3):164-166; doi:10.1093/ndtplus/sfn023
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Alloimmune haemolysis in a renal transplant recipient receiving sirolimus

Adam J. Hedley1, Shaun Flint1, Annabel Tuckfield2, Rowan Walker1 and Solomon Cohney1

1 Department of Nephrology
2 Department of Haematology, Royal Melbourne Hospital, Victoria, 3050 Australia

Correspondence: Shaun Flint, Department of Nephrology, Royal Melbourne Hospital, Victoria 3050, Australia. E-mail: shaun.flint@mh.org.au

Key Words: anti-ABO antibodies • haemolytic anaemia • passenger lymphocyte syndrome • renal transplantation

Received for publication December 16, 2007. Accepted for publication February 13, 2008.

The first 10% of the full text of this article appears below.


   Background
 
Anaemia commonly occurs following renal transplantation related to surgical blood loss, myelosuppression from immunosuppressive agents, antimicrobial prophylaxis and persisting renal impairment. A rare cause of anaemia after solid organ transplantation is alloimmune haemolysis due to antibodies from donor-derived lymphocytes accompanying the donor organ. We report the case of a 27-year-old patient receiving sirolimus who developed alloimmune haemolysis related to passenger lymphocytes. Although this has previously been reported in renal transplant recipients receiving a variety of immunosuppressive agents [11], to our knowledge this is the first case described in a patient receiving sirolimus.


   Case
 
A 27-year-old male received a renal transplant from his father after 2 years on maintenance haemodialysis for end-stage renal failure due . . . [Full Text of this Article]


   Discussion
 

   Conclusion
 

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