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NDT Plus Advance Access originally published online on February 14, 2008
NDT Plus 2008 1(2):112-116; doi:10.1093/ndtplus/sfn006
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management

Kim T. Sinnamon1, Aisling E. Courtney2, Camille Harron1, Declan M. O’Rourke3 and Robert N. Mullan1

1 Nephrology Unit, Antrim Area Hospital, 45 Bush Road, Antrim, BT41 2RL
2 Regional Nephrology Unit
3 Department of Pathology, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK

Correspondence: Kim Sinnamon, Nephrology Unit, Antrim Area Hospital, 45 Bush Road, Antrim, BT41 2RL, Northern Ireland, UK. Tel: +44-2894424000; Fax: +44-2894424883; E-mail: kimsinnamon@msn.com

Key Words: corticosteroids • tubulointerstitial nephritis • uveitis

Received for publication August 30, 2007. Accepted for publication January 9, 2008.

The first 150 words of the full text of this article appear below.


   Introduction
 
Acute tubulointerstitial nephritis is demonstrated in 2–3% of all native renal biopsies, increasing to 10–15% if the biopsy is performed in the setting of acute renal failure [1]. It is most commonly related to medication or infection [1,2]. An increasingly recognized entity is tubulointerstitial nephritis with uveitis (TINU) syndrome. We outline the clinical course of a patient with TINU syndrome and review the changes in epidemiology, diagnosis and management.


   Case
 
A 39-year-old man presented with a 6-month history of lethargy and generalized arthralgia. He also complained of urinary frequency and nocturia. His renal function was impaired with a creatinine of 257 µmol/L (estimated glomerular filtration rate, eGFR, 28 mls/min). He had received topical treatment for sudden-onset bilateral anterior uveitis 6 weeks previously but had no other significant past medical history. He took no regular medications and there had been no use of antibiotics or non-steroidal agents in . . . [Full Text of this Article]


   Discussion
 
Epidemiology
Pathophysiology
Clinical features
Management

   Teaching points
 

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