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NDT Plus Advance Access published online on November 3, 2009
NDT Plus, doi:10.1093/ndtplus/sfp151
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Problems of donor compatibility in a patient with sensitization to an alternate allelic variant of a ‘self’ HLA specificity

Pamela Koo1, Katherine McKinley1, Chas Newstead2 and Brendan Clark1

1 Department of Transplant Immunology
2 Department of Renal Medicine, St James's University Hospital, Leeds, UK

Correspondence: Brendan Clark; E-mail: Brendan.clarke{at}leedsth.nhs.uk


  Abstract

UK standards of deceased donor HLA typing and arrangements for reporting of recipient HLA antibody specificity can create a risk for ‘unexpected positive’ crossmatch that it is within the recipient centre's ability to avoid if high-confidence serum screening methods are in place. The case reported details investigations following an unexpected positive crossmatch due to an antibody directed against an allelic variant of a ‘self’ HLA specificity.

Key Words: allelic • antibody • crossmatch • HLA

Received for publication April 27, 2009. Accepted for publication September 28, 2009.


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