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NDT Plus Advance Access published online on October 7, 2009
NDT Plus, doi:10.1093/ndtplus/sfp141
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Hypocomplementaemic immune complex tubulointerstitial nephritis

Alok Gupta1, Serge Jothy2, Peter Somerville3 and Jeffrey S. Zaltzman4

1 Department of Nephrology
2 Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Canada
3 Department of Nephrology, Grand River Hospital, Kitchner-Waterloo, Canada
4 Department of Nephrology, St. Michael's Hospital, Toronto, Canada

Correspondence: Alok Gupta; E-mail: alok_bgupta{at}yahoo.co.in


  Abstract

We report a rare cause of rapidly progressive renal failure associated with low complement, positive ANA but negative anti DS-DNA. A renal biopsy demonstrated tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane but glomerular sparing. A review of the literature and differential diagnosis are discussed.

Key Words: hypocomplementaemic • immune complex • tubulointerstitial

Received for publication June 26, 2009. Accepted for publication September 7, 2009.


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