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NDT Plus Advance Access published online on September 19, 2009
NDT Plus, doi:10.1093/ndtplus/sfp125
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Fibrillary glomerulonephritis with prevalent IgA deposition associated with undifferentiated connective tissue disease: A case report

Manuela Nebuloni1,2, Augusto Genderini3, Antonella Tosoni1, Sabrina Caruso3 and Giovanni Barbiano di Belgiojoso3

1 Pathology Unit, L. Sacco Hospital
2 ‘L. Sacco’ Department of Clinical Sciences, University of Milan
3 Nephrology Unit, ‘L.Sacco’ Hospital, Milan, Italy

Correspondence: Manuela Nebuloni; E-mail: manuela.nebuloni{at}unimi.it


  Abstract

We described a 41-year-old female patient, who presented with proteinuria occurring 5 years after the onset of an undifferentiated connective tissue disease (UCTD). At renal biopsy, a pattern of focal necrotizing glomerulonephritis with mesangial and parietal deposition of the IgA, C3 and K chains was observed. Electron microscopy showed organized fibrillary deposits in mesangial, subendothelial, intramembranous and subepithelial sites. Fibrils were randomly arranged, had no hollow core and had a diameter ranging between 10 and 23 nm. This case showed a rare combination of fibrillary glomerulonephritis and prevalent IgA deposition, in the clinical context of UCTD.

Key Words: electron microscopy • fibrillary glomerulonephritis • IgA nephropathy • undifferentiated connective tissue disease

Received for publication March 4, 2009. Accepted for publication August 17, 2009.


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