NDT Plus Advance Access published online on September 3, 2009
NDT Plus, doi:10.1093/ndtplus/sfp119
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Nephrotic syndrome and renal failure as an unusual presentation of solid tumour
1 Departments of Nephrology, Erasme Hospital, Université Libre de Bruxelles, Brussels
2 Departments of Gynaecology, Erasme Hospital, Université Libre de Bruxelles, Brussels
3 Departments of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels
4 Department of Nephrology and Dialysis, RHMS Baudour Hospital, Baudour, Belgium
Correspondence: Frédéric Debelle; E-mail: fdebelle{at}ulb.ac.be
| Abstract |
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Glomerular diseases may occur as primary manifestation of cancer, especially in patients older than 60 years. Among glomerulopathies, membranous nephropathy is preferentially associated with respiratory and gastrointestinal tract adenocarcinomas, whereas minimal change disease is most often seen in haematological malignancies. Though breast cancer is one of the most frequent malignancies in women, paraneoplastic glomerular disease is rarely observed. We describe the case of a 79-year-old female patient who presented with nephrotic syndrome and renal failure. Breast cancer was found. Pathological studies of kidney and breast biopsy revealed a minimal change disease and an infiltrating ductal carcinoma, respectively.
Key Words: acute kidney injury minimal change disease nephrotic syndrome paraneoplastic glomerulopathy solid tumour
Received for publication January 26, 2009. Accepted for publication August 7, 2009.