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NDT Plus Advance Access originally published online on September 22, 2009
NDT Plus 2009 2(6):466-468; doi:10.1093/ndtplus/sfp113
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Acute renal failure, systemic lupus erythematosus and thrombotic microangiopathy following treatment with beta-interferon for multiple sclerosis: case report and review of the literature

Thomas Hansen1, David New1, Roy Reeve2, Rosemary Donne1 and William Stephens3

1 Renal Unit
2 Department of Pathology, Salford Royal NHS Foundation Trust, Salford, Greater Manchester
3 Department of Internal Medicine, Trafford Healthcare NHS Trust, UK

Correspondence: Correspondence and offprint requests to: Thomas Hansen; E-mail: thomas.hansen{at}student.manchester.ac.uk


  Abstract

We report a man with type 1 diabetes mellitus, autoimmune hypothyroidism and a tentative diagnosis of multiple sclerosis. Following treatment with beta interferon, he developed systemic lupus erythematosus with pericarditis, pleural effusions, cerebral infarction associated with anti-phospholipid antibody and acute renal failure due to thrombotic microangiopathy. He responded well to immunosuppression and anticoagulation. These complications may represent the most severe autoimmune reaction to beta interferon reported to date.

Key Words: acute renal failure • anti-phospholipid syndrome • beta-interferon • multiple sclerosis • systemic lupus erythematosus

Received for publication July 22, 2009. Accepted for publication July 27, 2009.


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