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NDT Plus Advance Access published online on August 18, 2009
NDT Plus, doi:10.1093/ndtplus/sfp109
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A case of adult atypical haemolytic uraemic syndrome related to anti-factor H autoantibodies successfully treated by plasma exchange, corticosteroids and rituximab

Arnaud Lionet1, François Provôt1, François Glowacki1, Veronique Frémeaux-Bacchi2 and Marc Hazzan1

1 Department of Néphrology, Hospital Calmette, CHRU-Lille, Lille
2 Department of Immunology, Höpital Europeen Georges Pompidou, Paris, France

Correspondence: Arnaud Lionet; E-mail: a-lionet{at}chru-lille.fr


  Abstract

Complement factor H auto-antibodies (CFH-ab) are a rare cause (6–10%) of atypical haemolytic uraemic syndrome (aHUS). All observations previously described were retrospective and occurred in children or teenagers. We report the first case of aHUS associated with anti-CFH antibodies in an adult patient who was successfully treated by plasma exchange, corticosteroids and rituximab.

Key Words: anti-CFH autoantibodies • atypical HUS • plasma exchange • rituximab

Received for publication July 17, 2009. Accepted for publication July 23, 2009.


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