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NDT Plus Advance Access published online on July 3, 2009
NDT Plus, doi:10.1093/ndtplus/sfp077
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Clarithromycin-induced acute interstitial nephritis and minimal change disease

Wendy Russell and William Smith

Renal Unit, Monklands Hospital, Airdrie ML6 0JS, Lanarkshire, UK

Correspondence: William Smith; E-mail: William.Smith{at}lanarkshire.scot.nhs.uk


  Abstract

Drug associated acute interstitial nephritis and minimal change disease has been well documented but the simultaneous presentation of both is rare and has not been reported with clarithromycin. We describe a case of simultaneous acute tubulointerstitial nephritis and minimal change disease induced by clarithromycin. The patient had acute kidney injury, nephrotic syndrome, eosinophilic pneumonitis and a maculopapular skin rash. The role of steroid therapy in acute interstitial nephritis is controversial but is accepted as beneficial in minimal change nephrotic syndrome. Steroid therapy in our patient resulted in complete clinical resolution.

Key Words: acute interstitial nephritis • clarithromycin • eosinophilic pneumonitis • nephrotic syndrome

Received for publication May 17, 2009. Accepted for publication June 11, 2009.


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