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NDT Plus Advance Access published online on April 28, 2009
NDT Plus, doi:10.1093/ndtplus/sfp048
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis

Elaine C. Jolly1, Menna R. Clatworthy2, Christopher Lawrence1, Paul D. Nathan3 and Ken Farrington1

1 Renal Unit, Lister Hospital, Coreys Mill Lane, Stevenage, Hertfordshire SG1 4AB
2 Renal Unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ
3 Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK

Correspondence: Elaine C. Jolly; E-mail: elainejolly{at}yahoo.co.uk


  Abstract

Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.

Key Words: acute renal impairment • CTLA-4 antibody • interstitial nephritis

Received for publication March 5, 2009. Accepted for publication April 7, 2009.


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