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NDT Plus Advance Access published online on March 4, 2009
NDT Plus, doi:10.1093/ndtplus/sfp028
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Membranous nephropathy associated with gastrointestinal stromal tumour: a case report

Adela Cimic1, Stephen O. Pastan2 and Vanesa Bijol1

1 Department of Pathology, Emory University Hospital
2 Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA, USA

Correspondence: Correspondence and offprint requests to: Adela Cimic; E-mail: cimicadela{at}yahoo.com


  Abstract

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in older adults. The association of MN with neoplasia has been controversial, but several recent studies have shown increase incidence of cancer in patients with MN [1]. We report a case of a 49-year-old male with severe nephrotic syndrome and concomitant jejunal gastrointestinal stromal tumour (GIST). The combination of preoperative Imatinib mesylate chemotherapy and tumour excision was followed by complete resolution of proteinuria within 19 months, without specific treatment for MN. An association between MN and GIST has never previously been reported in the literature.

Key Words: GIST • membranous nephropathy • proteinuria

Received for publication February 13, 2009. Accepted for publication February 16, 2009.


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