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NDT Plus Advance Access published online on November 25, 2008
NDT Plus, doi:10.1093/ndtplus/sfn180
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool

Viknesh Selvarajah1, Katie Lake1, Sue Robertson1, William Carman2, Chris Isles1 and on behalf of the Scottish Renal Registry

1 Department of Renal Medicine, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP
2 West of Scotland Specialist Virology Laboratory, Gartnavel General Hospital, Glasgow G12 0ZA, UK

Correspondence: Chris Isles, Department of Renal Medicine, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP, UK. Tel: +44-1387-241335; Fax: +44-1387-241361; E-mail: chris.isles{at}nhs.net


  Abstract

We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing that 1.8% of the Scottish adult transplant pool are susceptible to EBV infection. Though a vaccine for EBV is currently not yet available, routine screening of potential renal transplant recipients for EBV should help identify those at increased risk of post-transplant lymhoproliferative disorder (PTLD), while tailoring of immunosuppression and antiviral prophylaxis with Ganciclovir may help reduce the emergence of this potentially life-threatening disease.

Key Words: EBV • CMV • PTLD • renal • transplantation

Received for publication July 25, 2008. Accepted for publication October 27, 2008.


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