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NDT Plus Advance Access published online on July 4, 2008
NDT Plus, doi:10.1093/ndtplus/sfn098
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Membranoproliferative glomerulonephritis associated with an Epstein–Barr virus infection

Lazarus Karamadoukis1, Tibor Toth2 and Charlie Tomson1

1 The Richard Bright Renal Unit
2 Department of Histopathology, Southmead Hospital, Westbury on Trym, Bristol BS10 5BW, UK

Correspondence: Lazarus Karamadoukis, The Richard Bright Renal Unit, Southmead Hospital, Westbury on Trym, Bristol BS10 5BW, UK. Tel: 0117 959 5433; Fax: 0117 959 5432; E-mail: lazarus.karamadoukis{at}nbt.nhs.uk


  Abstract

Type 1 membranoproliferative glomerulonephritis (MPGN) is an immune complex-mediated disorder that has been associated with certain viral infections including hepatitis C, hepatitis B, hepatitis G, HIV and Hantavirus. We describe a patient with type 1 MPGN in native kidneys and nephrotic syndrome in whom there was strong evidence that a primary Epstein–Barr virus (EBV) infection played a causative role. This patient was treated with an angiotensin 2-receptor blocker and the nephrotic syndrome resolved within 6 months from presentation. Our case report suggests that MPGN presenting with nephrotic syndrome may have a relatively benign course when it is associated with an acute EBV infection.

Key Words: Epstein–Barr virus • membranoproliferative glomerulonephritis • nephrotic syndrome

Received for publication June 13, 2008. Accepted for publication June 17, 2008.


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