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NDT Plus 2009 2(Supplement 3):iii1-iii4; doi:10.1093/ndtplus/sfp152
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© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA].
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following NDT Plus issue: SIADH and Hyponatraemia [View the issue table of contents]

SIADH and hyponatraemia: foreword

Donal O’Donoghue1 and Anu Trehan2

1 Department of Nephrology
2 Department of Acute Medicine, Salford Royal Hospital, Salford, UK

Correspondence: Correspondence and offprint requests to: Donal O’Donoghue; E-mail: donal.o'donoghue{at}srft.nhs.uk


  Abstract

Hyponatraemia is common, affecting about one in five of all hospitalized patients. Minor degrees of chronic hyponatraemia cause cognitive and motor impairment, and severe hyponatraemia is associated with substantial morbidity and mortality. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatraemia and is often poorly understood and inappropriately treated. Clinical evaluation and simple biochemical assessment should guide management. The introduction of vasopressin antagonists, or vaptans, into clinical practice heralds the beginning of a new and exciting era for this important group of disorders.

Key Words: hyponatraemia • SIADH • vasopressin • vasopressin-receptor antagonists

Received for publication September 11, 2009. Accepted for publication September 29, 2009.


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