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NDT Plus Advance Access originally published online on February 26, 2009
NDT Plus 2009 2(3):246-249; doi:10.1093/ndtplus/sfp025
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection

Prue Hill1, John Slavin1 and David Goodman2

1 Department of Anatomical Pathology
2 Department of Nephrology, St Vincent's Hospital, Fitzroy 3065, Victoria, Australia

Correspondence: Correspondence and offprint requests to: Prue Hill, Department of Anatomical Pathology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia. Tel: +61-3-92884549; Fax: +61-3-92884580; E-mail: prue.hill{at}svhm.org.au


  Abstract

Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting.

Key Words: BK virus • kidney transplant • PVN • urothelial carcinoma

Received for publication October 8, 2008. Accepted for publication February 10, 2009.


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