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NDT Plus Advance Access originally published online on December 25, 2008
NDT Plus 2009 2(2):136-138; doi:10.1093/ndtplus/sfn197
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

A rare cause of nephrotic syndrome in autosomal-dominant polycystic kidney disease

Ray K. Wan1, David Kipgen2, Scott Morris3 and R. Stuart C. Rodger1

1 Renal Unit
2 Pathology Department, Western Infirmary General
3 Renal Unit, Glasgow Royal Infirmary, Glasgow, UK

Correspondence: Correspondence and offprint requests to: Ray K. Wan, Renal Unit Western Infirmary, Dumbarton Road, Glasgow, G11 6NT. Tel: +0141-211-1867; Fax: +0141-211-1711; E-mail: rkwan77{at}hotmail.com


  Abstract

We report the case of a 49-year-old lady who presented with hypertension, breathlessness and malaise. She was thrombocytopenic, with polycystic kidneys on imaging, and was found to have nephrotic syndrome. Serological results were consistent with systemic lupus erythematosus (SLE) and a renal biopsy confirmed WHO class V lupus nephritis. This is the first reported case of nephrotic syndrome due to lupus nephritis in a patient with autosomal dominant polycystic kidney disease (ADPKD) and underlines the importance of renal biopsy in patients with ADPKD and nephrotic range proteinuria.

Key Words: lupus • nephrotic syndrome • polycystic

Received for publication November 25, 2008. Accepted for publication November 27, 2008.


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