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NDT Plus 2008 1(Supplement 4):iv46-iv50; doi:10.1093/ndtplus/sfn124
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following NDT Plus issue: Dialysis Initiatives May 2007, Berlin, Germany [View the issue table of contents]

Conventional versus biocompatible peritoneal dialysis fluids: more questions than answers?

Karima Farhat, Frans Jan van Ittersum, Piet Marten ter Wee and Caroline Ellen Douma

Department of Nephrology, VU Medical Centre, Amsterdam, The Netherlands

Correspondence: K. Farhat, Department of Nephrology, VU Medical Centre, PO Box 7075, 1007 MB Amsterdam, The Netherlands. Tel: +0031-044-2673; Fax: +0031-044-2675; E-mail: k.farhat{at}vumc.nl


  Abstract

The most important challenge in peritoneal dialysis (PD) is long-term preservation of peritoneal membrane structure and function. Introduction of dialysis fluids into the peritoneal cavity induces changes. These changes are related to duration of dialysis, occurrence of peritonitis and components of the dialysis solution. Bioincompatibility is considered to be the major cause of the development of morphological changes of the peritoneal membrane. pH neutral PD fluids that are low in glucose degradation products (GDP) seem to better preserve the peritoneal membrane and have less systemic effects than the conventional ones. However, the long-term effects are not clear. An overview of the effects of conventional PD fluids and glucose-based PD fluids with neutral pH in ex vivo and in vivo animal and clinical studies is presented.

Key Words: biocompatibility • peritoneal dialysis fluids • peritoneal dialysis

Received for publication February 19, 2008. Accepted for publication June 19, 2008.


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