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NDT Plus 2008 1(Supplement 4):iv18-iv22; doi:10.1093/ndtplus/sfn119
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following NDT Plus issue: Dialysis Initiatives May 2007, Berlin, Germany [View the issue table of contents]

Clinical effects of icodextrin in peritoneal dialysis

Trijntje T. Cnossen1, Constantijn J. Konings2, Frank M. van der Sande1, Karel M. Leunissen1 and Jeroen P. Kooman1

1 Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, the Netherlands
2 Department of Nephrology, Catharina Hospital, Eindhoven, The Netherlands

Correspondence: Trijntje T. Cnossen, MD Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands. Tel: +31-43-3875007; E-mail: nynke.cnossen{at}mumc.nl


  Abstract

Objective. This study reviews the relevant publications on the clinical effects of icodextrin in peritoneal dialysis (PD).

Design. The study provides a systematic review of the literature (MEDLINE search with icodextrin as the keyword).

Results. Icodextrin induces sustained transcapillary ultrafiltration during long dwell periods. It also stimulates increased removal of sodium by the peritoneal membrane, reduction of extracellular water (ECW) and total body water (TBW). Effects of icodextrin on blood pressure control and residual renal function are discrepant. Icodextrin induces a reduction in the formation of advanced glycation end-products, while the longitudinal changes in the peritoneal membrane transport are less prominent.

Conclusions. Use of icodextrin in PD improves the sodium and fluid balance. Icodextrin is potentially more biocompatible, when compared with the conventional glucose solutions. The side effects are rare.

Key Words: icodextrin • fluid status • sodium balance • residual renal function • side effects

Received for publication March 6, 2008. Accepted for publication June 19, 2008.


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