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NDT Plus 2008 1(Supplement 1):i7-i11; doi:10.1093/ndtplus/sfm038
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© The Author [2007].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

The Role of the Calcium-Sensing Receptor in the Pathophysiology of Secondary Hyperparathyroidism

Daniela Riccardi1 and David Martin2

1 Cardiff School of Biosciences, Cardiff, UK
2 Amgen Inc, Thousand Oaks, CA, USA

Correspondence: Daniela Riccardi, Cardiff School of Biosciences, Biomedical Building, Museum Avenue, Cardiff CF10 3US, UK. E-mail: Riccardi{at}cardiff.ac.uk


  Abstract

The calcium-sensing receptor (CaR), a seven-transmembrane domain receptor belonging to the G protein-coupled receptor family, is responsible for calcium-mediated signalling initiated at the surface of parathyroid cells that controls the synthesis and secretion of parathyroid hormone (PTH). Expression of the CaR is downregulated in animal models of uraemia and in patients with secondary hyperparathyroidism (SHPT). Cinacalcet is a type II calcimimetic agent that acts as an allosteric modulator of CaR signalling. It has been shown in clinical studies to improve control of serum PTH levels and in preclinical studies to attenuate SHPT disease progression and parathyroid hyperplasia. Cinacalcet represents the first of this novel class of agents and a major advance in the treatment of SHPT.

Key Words: calcium-sensing receptor • chronic kidney disease • cinacalcet • parathyroid hormone • secondary hyperparathyroidism

Received for publication July 17, 2007. Accepted for publication September 10, 2007.


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