NDT Plus Advance Access originally published online on September 1, 2008
NDT Plus 2008 1(6):412-413; doi:10.1093/ndtplus/sfn137
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Lanthanum carbonate possibly responsible for acute liver failure in a patient with Child–Pugh stage A liver cirrhosis
Department of Nephrology and Hypertension, UZ Brussel, Jette, Belgium
Correspondence: Correspondence and offprint requests to: K. De Leeuw, Department of Nephrology and Hypertension, UZ Brussel, Laarbeeklaan 101, 1090 Jette, Belgium. Tel: +32-2-477-6055; Fax: +32-2-477-6230; E-mail: Kathleen.DeLeeuw{at}uzbrussel.be
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Abstract |
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The majority of patients with end-stage renal disease have hyperphosphataemia, which is associated with significant morbidity and mortality. Lanthanum carbonate has been introduced as a new treatment modality to lower serum phosphorus. But there has been ongoing concern about lanthanum accumulation in tissues, especially in liver. We describe the case of a woman with pre-existing liver disease, who presented with acute liver failure after introduction of lanthanum carbonate to her treatment. The condition was fully reversible after stopping lanthanum carbonate.
Key Words: chronic renal failure • lanthanum carbonate • liver disease • phosphor
Received for publication July 22, 2008. Accepted for publication August 1, 2008.
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 M. Smyth, B. Gellert, and R. D. Pratt Comment on: 'Lanthanum carbonate possibly responsible for acute liver failure in a patient with Child-Pugh stage A liver cirrhosis' NDT Plus, June 1, 2009; 2(3): 265 - 266. [Full Text] [PDF]
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